Etoricoxib

DB01628ApprovedInvestigationalWithdrawnSmall molecule

Etoricoxib is a selective COX-2 inhibitor used to relieve moderate post-surgical dental pain as a short-term treatment and inflammatory and painful symptoms of various forms of arthritis. Current therapeutic indications are: treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, chronic low back pain, acute pain and gout.

Chemical structure of Etoricoxib
Mechanism
Curator reviewed
Primary indication
For the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, chronic low back pain, acute pain and gout.Curator reviewed · 5 structured indications
Formula / weight
C18H15ClN2O2S · 358.842 g/mol (avg)
Code names
L-791456 · MK-0663 · MK-663

Resolves to

Compound
UNIIWRX4NFY03RCAS202409-33-4ChEMBLCHEMBL416146ChEBI6339PubChem123619KEGGD03710
Clinical / RWD
RxNorm307296ATCM01AH05PharmGKBPA164776853
Structure
InChIKeyMNJVRJDLRVPLFE-UHFFFAOYSA-NSMILESCC1=NC=C(C=C1)C1=C(C=C(Cl)C=N1)C1=CC=C(C=C1)S(C)(=O)=O
Targets
P35354PTGS2

What you can answer from here — as of September 16, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action
Listed above
1,863Drug interactionsStructured to mechanism, not free text
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100Clinical trialsPhase, status and sponsor resolved per trial
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5Structured indicationsCondition, population, route and combination as fields, not prose
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14ContraindicationsEach with its own population and attribute set
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1,275Marketed productsAcross 8 countries and 105 labellers
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1ATC codeIncluding every combination product, plus 37 drug categories
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24+ReferencesStructured and connected to the statements they support
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